Paturu Kondaiah                                     Back to Home Page

Professor

Ph.D. 1982 (Genetics), Osmania University, Hyderabad       

Post-doctoral training:Laboratory of Chemoprevention,

National Cancer Institute, USA (1983-1990)

E-mail: paturu@mrdg.iisc.ernet.in; Tel: 91-80-2932688

 

Current research

The research goals of this laboratory are to understand tissue specific regulation of eukaryotic gene expression with a broader question on how these specificities contribute to a disease process.  Currently the emphasis is on a family of growth inhibitory genes and hormone regulated genes.  Recent research in the laboratory has resulted in 1) understanding the mechanism of estrogen regulated gene expression mediated by ERE half sites; 2) regulation of a TGF-beta gene by muscle specific transcription factor, MyoD and heart specific transcription factor, NKx 2.5; 3) the identification of several novel genes regulated by androgens in the rat ventral prostate; 4) differential regulation of gene expression by testosterone and anti androgen, flutamide.  In addition, modified novel triterpenoids from plant sources have been characterized for their anti inflammatory and anti growth potential.  Future goals include studies on the contribution of TGF-beta pathway in oral and cervix cancers, expression profiling of genes differentially regulated during cancer progression etc.  The laboratory has several local and international collaborative research projects that include scientists from NIH (USA), Dartmouth Medical School (USA), Organic Chemistry at IISc, NIN (Hyderabad), NIMHANS Bangalore and TTK blood bank, Bangalore.   The techniques that are employed include, RNA profilling using Northern blots and RT-PCR, Differential Display RT-PCR, gene micro array technologies, cloning and characterization of gene promoters etc.  The laboratory is adequately equipped and has (or access to) CO2 incubators, centrifuges, vacuum blotting apparatus, low temperature water bath, shaking water bath, gel documentation system, hybridization oven, speedvac/gel drier, luminometer, micro array facilities, hybridization chambers, real time PCR machines, Proteomics facilities, and other items.  The research in the laboratory is supported by funds from various sources including, NIH (USA), DBT, DST, CSIR, ICMR and Sir Dorabji Tata Centre.

 

Current Students:

Anil Limaye, Prathibha Ranganathan, Thangjam Gagan Singh, Poulomi Bhanja. Mahalakshmi  

 

Post Doc:

Vijayalakshmi N,

 

Project Assistant:

 Hanuma Kumar .

 

 

 

Bibliographical information about the supervisor

 

Manuscripts published:   47  Chapters in books:  1

 

Selected publications

 

1.     Sumathy, K., Desai, K.V. and Kondaiah, P.: Isolation of transforming Growth factor-b2 cDNA from a fish, Cyprinus carpio by RT-PCR. Gene  191, 103-107. 1997.  

 

2.    Vempati, U.D. and Kondaiah, P.:  Sequence analysis of the 5' flanking region of the TGF-b5 gene from Xenopus laevisGene. 208, 323-329, 1998.  

 

3.     Desai, K.V., Flanders, K.C. and Kondaiah, P.: Expression of TGF-bisoforms in the rat male accessory sex organs and Epididymis. Cell and Tissue Res, 294 (2) 271-277. 1998.  

    

    Desai K.V. and Kondaiah P.: Androgen ablation results in differential regulation of transforming growth factor - b isoforms in the rat male accessory organs and epididymis. J. Mol. Endocrinol. 24, 253-260. 2000.  

 

5.     Kondaiah P. Taira, M, Vempati U.D. and Dawid, I.B.: Transforming Growth Factor-b5 expression

      during early development of Xenopus laevis. Mech. Dev. 95, 207-209. 2000.  

 

.     Dhanasekaran S.M., Vempati U.D. and Kondaiah, P.:  Isolation and Characterization of a Transforming  Growth Factor-b type II receptor cDNA from Xenopus laevis. Gene 263 (1-2), 173-181,2001

7.     

          Vasudevan N., Bahadur, U and Kondaiah, P.: Characterization of chicken riboflavin carrier protein (RCP) gene structure and promoter regulation by estrogen.  J. Biosci.  26 (1) 39-46 2001.

8.     

         Goswami MT, Desai KV and Kondaiah P.:  Comparative functional analysis of rat TGF-b1 and Xenopus TGF-b5 promoters reveal differential regulation.  J. Mol. Evo. 57(1):44-51, 2003.