Department of Molecular Reproduction, Development and Genetics
Indian Institute of Science, Bangalore



• Nair, R.R., Kiran, A. and Saini, D.K. G protein Signaling, Journeys Beyond the Plasma Membrane. (2017) J. Ind. Inst. Sci. In Press.


• Jain, R., Watson, U. and Saini, D.K. ERK activated by Histamine H1 receptor is anti-proliferative through spatial restriction in the cytosol. (2017) Eur J. Cell Biol. In Press. Link


• Bagheri M., Nair, R.R., Singh, K.K. and Saini, D.K. ATM-ROS-iNOS axis regulates nitric oxide mediated cellular senescence. (2016) Biochim Biophys Acta. (Mol Cell Res) S0167-4889(16)30294-4. Link


• Narayanaswamy, N., Nair, R.R., Suseela, Y.V., Saini, D.K. and Govindaraju, T. Molecular beacon-based DNA switch for reversible pH sensing in vesicles and live cells. (2016) Chem. Commun. 5;52(56):8741-4. Link


• Singh, K.K., Jain, R., Ramanan, H. and Saini, D.K. Expression and purification of matrix metalloproteases in Escherichia coli. (2015) Meth. Mol. Biol. In Press. Link


• Narayanaswamy, N., Narra, N., Nair, R.R., Saini, D.K., Kondaiah, P. and Govindaraju, T. Stimuli-Responsive Colorimetric and NIR Fluorescence Combination Probe for Selective Reporting of Cellular Hydrogen Peroxide. (2016)Chem. Sci. In Press. Link


• Sunilkumar, B., Ravikumar, K., Saini, D.K. and Basu, B. Differential viability response of prokaryotes and eukaryotes to high strength pulsed magnetic stimuli (2015) Bioelectrochem. 106(Pt B):276 – 89.



• The Two Component Signaling Networks of Mycobacterium tuberculosis Displays Extensive Crosstalk In Vitro. Agrawal et al. (2015) Biochem. J. In Press.  Link


• M. tuberculosis Response Regulators, DevR and NarL Interact In Vivo and Co-Regulate Gene Expression during Aerobic Nitrate Metabolism. Malhotra et al. (2015) J. Biol. Chem. 290, 8294 – 8309.  Link


• Temporally Distinct Roles of ATM and ROS in Genotoxic Stress Dependent Induction and Maintenance of Cellular Senescence. Nair et al. (2015) J. Cell Sci. 128, 342 - 353.  Link


• Agrawal, R. and Saini, D.K. Rv1027c-Rv1028c encode functional KdpDE two - Component system in Mycobacterium tuberculosis. (2014)Biochem Biophys Res Commun. 2014 Apr 18;446(4):1172-8. Link


• Jain, R. and Saini, D.K. Imaging cellular signaling: Many 'moving tales' in MAP kinase odyssey. (2013) Current Science. 105(11), 1512-1523. Link


• Agrawal, R., Hariharan, V.N. and Saini, D.K. Two - Component Signaling Systems of M. tuberculosis: Regulators of Pathogenicity and More. (2013). "Dynamic Models of Infectious Diseases - Vol.2" Editor, Rao, V.S.H. & Durvasula, R. Publisher, Springer, USA. Chapter 4, pages 79-110.


• Hariharan, V.N., Nair, R.R. and Saini, D.K. A Serpentine Way to Signalling - The Nobel Prize in Chemistry. (2013) Resonance Vol. 18(6), 397 - 409.


• Cho, J.H.*, Saini, D.K.*, Karunarathne, W.K.A., Kalyanaraman, V. and Gautam, N.  Alteration of Golgi structure in senescent cells and its regulation by a G protein gamma subunit. (2011) Cellular Signaling. 23(5):785-93. (*Equal contribution). Link


• Saini, D.K., Karunarathne, W.K.A, Angaswamy, N., Saini, D., Cho, J-H., Kalyanaraman, V. and Gautam, N. Regulation of Golgi Structure and Secretion by Receptor induced G protein betagamma Complex Translocation. (2010) Proc. Natl. Acad. Sci. USA.107(25):11417-22. Link


• Saini, D.K. and Gautam, N. Live cell imaging for studying GPCRs activation in single cells. (2010) Methods Mol. Biol. 617: 191-207. Link


• Chisari, M., Saini, D.K., Kalyanaraman, V. and Gautam, N. G protein subunit dissociation and translocation regulate cellular response to receptor stimulation. (2009) PLoS One. 4(11): e7797. Link


• Saini, D.K., Chisari, M. and Gautam, N. Shuttling and Translocation of Heterotrimeric G Proteins and Ras. (2009) Trends Pharmacol. Sci.  30(6): 278-86.  Link


• Saini, D.K., Kalyanaraman, V., Chisari, M. and Gautam, N. A family of G protein betagamma subunits translocate reversibly from the plasma membrane to endomembranes on receptor activation. (2007) J Biol Chem. 282: 24099-108. [Comment - A Moving Story. Sci. STKE 2007, tw301 (2007)] Link


• Chisari, M., Saini, D.K., Kalyanaraman, V. and Gautam, N. Shuttling of G protein subunits between the plasma membrane and intracellular membranes. (2007) J Biol Chem. 282: 24092-8. [Comment - A Moving Story. Sci. STKE 2007, tw301 (2007)] Link


• Saini, D.K. and Tyagi, J.S. High throughput microplate phosphorylation assays based on DevR-DevS /Rv2027c two-component signal transduction pathway to screen for novel anti-tubercular compounds.  (2005) J. Biomol. Screen. 10: 215-224. Link


• Saini, D.K., Malhotra, V. and Tyagi, J.S. Cross talk between DevS sensor kinase homologue, Rv2027c, and DevR response regulator of Mycobacterium tuberculosis. (2004) FEBS Lett. 565, 75. Link


• Saini, D.K., Malhotra, V., Dey, D., Pant, N., Das, T.K. and Tyagi, J.S.  DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.  (2004) Microbiology 150, 865-875. Link


• Malhotra, V., Sharma, D., Ramanathan, V., Shakila, H.S., Saini, D.K., Chakravorty, S., Das, T.K., Li, Q., Silver, R.F., Narayanan, P.R. and Tyagi, J.S.  Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis. (2004) FEMS Microbiol. Lett. 231, 237. Link


• Tyagi, J.S. and Saini, D.K.  Did the loss of two component systems initiate pseudogene accumulation in M. leprae?  (2004) Microbiology 150, 4-7.  Link


• Saini, D.K., Pant, N., Das, T.K. and Tyagi, J.S.  Cloning, overexpression, purification and matrix assisted refolding of DevS (Rv3132c) Histidine Protein Kinase of Mycobacterium  tuberculosis.  (2002) Protein Express Purif. 25, 203-208. Link




• Umapathy, S., Saini, D.K. and Kumar, S. Spectroscopic Identification and Characterization of Bacterial Species – Application in Diagnosis. Invention disclosure filed.


• Tyagi, J.S. and Saini, D.K. (2003) Patent No. WO/2004/036224. International Application No. PCT/IB03/04555. Publication Date. 29.04.2004. A screening method for developing drugs against pathogenic microbes having two-component system.


• Tyagi, J.S. and Saini, D.K. (2009) A screening method for developing drugs against pathogenic microbes having two-component system. US patent No. 7,566,550.


• Tyagi, J.S., Bagchi, G., Mayuri, Kumra, N., Kaur, K., Saini, D.K. and Tyagi, A.K. (2004). A simple and fast process for evaluating Mycobacterium tuberculosis promoters under hypoxic and aerobic

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Last updated on 3-2-2017