Morphology and Microenvironment
MBBS: Calcutta Medical College, University of Calcutta
PhD: New York Medical College
Postdoctoral Fellowship: Lawrence Berkeley National Laboratory
The behavior and functions of a tissue or organ is the cumulative result of the interactions between its cells and their microenvironment, the molecules of which comprise secretory and matrix proteins, as well as sugars. The information stored by the spatiotemporal patterns of sugars, as decorations of glycoproteins, or as constituents of proteoglycans (PGs) is known as the glycocode. The glycocode is involved in, and changes in a dynamical manner during, development as well as in cancer. We will study the significance of the dynamics of sugars and their interacting proteins during development (limb: a mesenchymal organ, and breast: an epithelial glandular organ) and during cancer (breast cancer and metastasis).
1. Lee SE, Chen Q*, Bhat R*, Petkiewicz S, Smith JM, Ferry V, Correia A, Alivasatos AP, Bissell MJ. Reversible Aptamer-Au plasmon rulers for secreted single molecules. Nanoletters. 2015 (in press)
2. Gomes AM*, Bhat R*, Correia A-L, Ilan N, Vlodavsky I, Bissell MJ. Mammary branching morphogenesis requires reciprocal signaling by heparanase and MMP-14 (*equal contribution) J Cell Biochem. 2015 (in press).
3. Chuong C-M, Bhat R, Widelitz R and Bissell, MJ. (2014) Snapshot: Branching Morphogenesis. Cell 158 (5):1212-1212.e1.
4. Bhat R, Chakraborty M, Mian IS and Newman SA. (2014) Structural divergence in vertebrate phylogeny of a duplicated prototype galectin Gen Biol Evol. 6(10): 2721-30.
5. Bhat R (2014). Understanding Complexity through pattern languages in biological and manmade architectures Int J Architect Res. 8:8-19.
6. Bhat R and Bissell, MJ. (2014) Of plasticity and specificity: dialectics of the microenvironment and macroenvironment and the organ phenotype. WIRES Dev Biol. 3, 147-163.
7. Glimm T, Bhat R and Newman SA. (2014) Modeling the morphodynamic galectin patterning network of the developing avian limb skeleton. J Theor Biol. 346:86-108.